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Abstract
Despite many years of research to control and eradicate the disease, malaria, caused by parasites of the genus Plasmodium, continues to be a worldwide health burden. While much focus has been placed on the properties of the infecting parasites, recently more attention has been given to interactions between the host and the parasite, which drive clinical outcomes. To investigate the underlying pathways in host responses, whole blood transcriptome, plasma metabolome, and proteome analysis were performed during the peak of parasitemia from two longitudinal experimental malaria studies encompassing two different nonhuman primate host species (Macaca mulatta and Macaca fascicularis) infected with P. knowelsi.