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Abstract
Quercetin, a flavonoid, is cytotoxic to human tumor cells at high concentrations. The objective of the present study was to determine if cellular iron status influences quercetin-stimulated cytotoxicity and apoptosis in a human hepatoblastoma cell line. To test the hypothesis, cell viability, lipid peroxidation, and apoptosis were measured in HepG2 cells following treatment with various levels of iron and quercetin. The data suggest that Fe concentration may influence quercetins effect on cell viability and apoptosis in HepG2 cells.