Schistosomiasis is an underreported infection that can cause anemia, decreased growth, liver abnormalities, and deficits in cognitive functioning to children. This study used Behavior Assessment System for Children (BASC-2) to collect the raw data of childrens behaviors with or without schistosomiasis in Kenya before and after mass drug administration (MDA) with praziquantel. We performed multiple imputation to deal with the missing data, and applied several statistical procedures such as paired t-test and linear mixed effect models to investigate the impact of schistosomiasis infection on childrens behavior and whether the MDA leads to positive effects on childrens behaviors. The results of this study generally supported our expectation that children have better behaviors without schistosomiasis, and childrens behaviors, especially problematic behaviors, will improve significantly after the praziquantel treatment.