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Abstract
Non-typhoidal Salmonella originating from chicken is a leading cause of gastroenteritis in humans. A commercial vaccine against Salmonella enterica Enteritidis in broilers has not be successful due to various reasons. An oral subunit vaccine has the potential to induce immunity in the gut of broilers, the primary site of colonization. An oral nanoparticle vaccine consisting of flagella and OMP A antigens extracted from S. Enteritidis and encapsulated within polyanhydride was tested in two studies. The first study looked at determining the optimum dosage of the vaccine and the second study aimed at determining the efficacy of the vaccine following a S. Enteritidis challenge. A dose of 250 g with one booster induced humoral immunity in birds through production of anti-Salmonella IgA antibodies (P < 0.05). This vaccine showed potential for inducing long-lasting mucosal immunity in broilers.