Italian ryegrass [Lolium perenne ssp. multiflorum (Lam.) Husnot] is known for being the most troublesome weed in small grains in Georgia. This Lolium species is also a highly recommended cool-season forage that becomes problematic when total control is never achieved in warm-season bermudagrass or tall-fescue hayfields. Concerns about the lack of control in Italian ryegrass require Georgia populations be evaluated. Therefore, the response of Italian ryegrass populations to small grain herbicides was assessed. Greenhouse experiments from 2015 to 2017 indicate that post-emergence use herbicides lack control of some Georgia commercialized Italian ryegrass cultivars and farm-collected biotypes. A continuation of these experiments within the field setting are needed to determine if the responses can be replicated, and further analyses on other ryegrass populations should be conducted to determine if these trends are developing in experimental seed lots and currently available populations.