School-Age Children (SAC) in Low-Middle-Income Countries (LMICs) such as Ghana are the most affected by a heavy burden of helminthiasis and its resultant undernutrition and poor cognitive outcomes. This dissertation sought to examine the prevalence rates of helminths, undernutrition and cognitive performance of SAC in two (2) unique communities (farming and fishing) in a rural area in Ghana, and to compare different interventions in the control of helminthiasis and its resultant undernutrition and cognition in the two communities. Three main areas covered in this dissertation are: (i) disparities of helminthiasis prevalence, sanitary conditions/habits of SAC, (ii) predictors of undernutrition and cognitive deficits among SAC in the two communities, and (iii) impact of interventions on the nutritional status (BAZ, HAZ, anemia and zinc deficiency) and cognitive performance of SAC. Children in the fishing community had the heaviest schistosome infection and overall poor nutritional status, poor sanitation and hygienic practices. Independent predictors of anemia were helminthiasis status and pica behavior. Zinc deficiency was significantly higher among children in the farming community (p<0.0001). The intervention arm with the greatest improvement in the mean BAZ (0.270.81) (p=0.002), HAZ (0.160.38) (P<0.001) and Hb levels (1.2213) (p<0.0001) was the NutEd Only group. Whereas the greatest improvement in blood zinc levels occurred in the NutEd+Suppl group (46.3922.3) (p<0.0001). The highest improvement in the mean cognitive test score occurred in the Suppl Only group (3.08 6.07) (p<0.0001). A univariate analysis revealed that compared to the Control group, the NutEd Only group was significantly associated with less likelihood of stunting (OR=0.205, CI; 0.04-0.10). Also, being in the NutEd Only group(R=0.29, CI; 0.13-0.69) and the NutEd+Suppl group (OR=0.34, CI; 0.13-0.85) were significantly associated with less likelihood of anemia. However, the NutEd Only group (OR=6.40, CI; 1.39-29.50) and the Suppl Only group (OR=6.04, CI; 1.27-28.77) were significantly associated with a higher likelihood of zinc deficiency. Thus, our study showed that combining nutrition education with micronutrient supplementation together with ongoing deworming interventions will potentially yield significant improvement in undernutrition and cognitive outcomes in SAC.