There has been a substantial amount of editorial discussion regarding sustainability in the fashion industry, but there lacked extensive research examining purchase frequency towards secondhand clothing. This research examined the influence of consumers sustainability and their fashion lifestyle towards their purchase frequency of secondhand clothing. Secondhand apparel and accessory shoppers in Athens, Georgia were quantitatively analyzed through their participation in an online survey. The results showed significant influence of Environmental Apparel Consumerism, Apparel Knowledge and Concern for Apparel Social Issues, Fashion Leadership, and Shopping Enjoyment on Purchase Frequency of secondhand apparel and accessories.