For a functional brain development neural circuits must be organized precisely. Any aberrations throughout the development of connectivity of the neural circuit can lead [...]

Understanding how the neuronal circuitry functions at the cellular and molecularlevels is critical for unraveling deeper insights about neurological disorders. This study[...]

The oxidative environment of the endoplasmic reticulum (ER) facilitates disulfide bond formation, a process that is critical for correct protein folding. Protein disulfid[...]

Amyotrophic lateral sclerosis (ALS) is a devastating neuromuscular disease characterized by motor neuron degeneration and muscle atrophy, with no effective treatments. Gi[...]

Androgen receptor (AR) signaling continues to drive disease progression in a large fraction of castration-resistant prostate cancer (CRPC) after androgen deprivation ther[...]

Not much has been revealed about how organelles are assembled into patterns inside cells. Ciliates are good models to study intracellular pattern formation due to the com[...]

Chlamydomonas PKD2 localizes into two distinct ciliary compartments (zones). In the distal cilium, PKD2 anchors mastigoneme in two rows. The distal PKD2 is stably connect[...]

Lysine acetylation of lpha tubulin is a conserved post-translational modification that is present on microtubules in many structures including cilia, neuronal projections[...]

Apicomplexa are a diverse and medically important group of obligate intracellular parasites. Most apicomplexans harbor a non-photosynthetic plastid (called apicoplast) th[...]

Protein degradation through cullin-RING ubiquitin ligases (CRLs) is required for theregulation of various cellular processes. Here we describe the regulation of mitotic p[...]

Cilia are microtubule-based organelles adapted to multiple functions in eukaryotic organisms, including locomotion, feeding, movement of extracellular fluid, and various [...]

The genus Ploeotia represents a group of small, colorless, heterotrophic euglenids commonlyfound in shallow-water marine sediments. Species belonging to this genus have h[...]

My doctoral research centered on understanding the evolution of the euglenophyte protists, with special attention paid to their plastids. The euglenophytes are a widely d[...]

In contrast to antigen-independent, cytokine-driven CD8+ T cell memory arising from acute resolving infections, CD8+ T cell memory during chronic infections is thought to[...]

New drugs are needed for human African trypanosomiasis (HAT) caused by subspecies of Trypanosoma brucei as drug resistance and toxic side effects plague current therapies[...]

Toxoplasma gondii is an opportunistic protozoan parasite of fetuses from infected mothers and of immuno-compromised patients. Limitations of current treatments and unavai[...]

Scientists and philosophers have marveled over the complex nature of the vascular system for many centuries. In this dissertation work, we were interested in unraveling t[...]

Chromatin insulators are widely distributed in the genome and mediate formation of chromatin loops, but their roles in gene regulation remain poorly understood. The compl[...]

Cullins function in multisubunit ubiquitin ligase (E3) complexes to promote the ubiquitin-mediated proteolysis of substrates and regulate a wide range of cellular process[...]

Trypanosoma cruzi is the etiologic agent of Chagas disease. It contains a Contractile Vacuole Complex (CVC) that plays a vital role in the regulation of its cell volume a[...]

Communication between cells is a highly regulated process that requires selective control of signaling events to ensure proper development of tissues. Within all metazoan[...]

Aniridia is a rare congenital eye disorder typically diagnosed postnatally by partial or full iris hypoplasia. Associated foveal hypoplasia, indicated by early infancy ny[...]

The CDK-cyclin complex is the major regulator of cell cycle. Multiple mechanisms control the CDK-cyclin complex activity, among them there are two important mechanisms: t[...]

Apicomplexan parasites are important pathogens responsible for economically important as well as life threatening infections in humans and animals. Poor efficacy and emer[...]

Chromatin boundaries, or insulators, partition the genome into structural and functional domains. Previous studies show that insulators can modulate enhancer-promoter int[...]